Literature summary

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The Literature pages summarise published research so that clinicians can find and read the original papers. HANS Korea has no intention of infringing anyone’s copyright, trademark or other intellectual-property rights: quotations are brief and attributed, every entry links to the publisher’s own page, no full text or figure is reproduced, and no comparative claim is made about any other manufacturer’s product. If you are an author, publisher or manufacturer and have any concern about how your work or product is referred to on this site, please contact [email protected]. We will review it promptly and correct or remove the material. Conversely, the summaries, tables, compiled figures, images and documents prepared by HANS Korea for this site are its own work: their use by any third party — in particular by a manufacturer, importer or seller of a similar device — for promotion, product development or any other purpose requires the prior written consent of HANS KOREA CO.,Ltd.

The figures, and how they are counted Revision 2 · 12 October 2026

Every number HANS Korea quotes about the literature comes from the thirty-four papers on the Published studies page and nothing else. This page shows the counting rules and the lists behind each figure, so that a reader can check them.

34Verified publications
20Countries
59Universities & institutions
141Investigators
723Patients
≥ 1,088Implants treated
6~120Months follow-up

Figures, counting rules, the 59 institutions, the 141 investigators and the per-study patient table in one document. Revision 2 · 12 October 2026.

FigureCounting ruleSource
34 publicationsA paper is counted only when it has been read in full, verified against the publisher’s record, and names the instrument as the NiTi Brush of HANS Korea in its text or figures, under its current name, its former name I.C.T. (Implant Cleaning Technique), or the RotoBrush name used by HANS Korea’s United States distributor, Salvin Dental Specialties. Papers reporting merely “a titanium brush” are excluded. Nine randomised-controlled-trial publications and one quasi-randomised controlled trial, nine clinical studies (a retrospective cohort, retrospective analyses, case series and case reports), eleven translational and laboratory studies (one of them in an animal model, one a doctoral thesis), four reviews.Publisher records (CrossRef, PubMed, J-STAGE), full texts
20 countriesCountries of the authors’ affiliations as printed in each paper; a country is counted once however many papers or authors it appears in.Author affiliations
59 institutionsUniversities, university hospitals, research institutes and named clinics in the authors’ affiliations, each counted once. Affiliations given only as “private practice” without a name are not counted.Author affiliations
141 investigatorsEvery named author across the thirty-four papers, counted once regardless of how many papers they appear in.Author lists (CrossRef, PubMed, paper)
723 patientsSum of the patients treated in the fifteen clinical studies that report them. Where two papers report the same patients (the 1-year and 3-year reports of one trial; a trial and its secondary analysis; a single-centre report of a multicentre trial; a retrospective cohort that covers the same centre and period as an earlier report) the cohort is counted once. In the one randomised trial where the brush was used in one arm only, only that arm is counted. Translational and laboratory studies and reviews contribute none.Methods / Results of each paper
≥ 1,088 implantsSame rule for implants. One multicentre trial reports patients but not implants; it is counted as one implant per patient, so the total is a minimum.Methods / Results of each paper
6~120 monthsShortest and longest follow-up reported in the clinical studies: 6 months (Galarraga-Vinueza et al. 2020; Malmqvist et al. 2025) to 120 months (Parma-Benfenati et al. 2026, a 10-year case report). Among the cohort studies the longest follow-up is 42 months (Brincat et al. 2023); the 3-year trial report covers 36 months.Methods of each paper

Countries and institutions 59 institutions in 20 countries

CountryUniversities, hospitals, research institutes and named clinics
SpainComplutense University of Madrid (ETEP Research Group) · Universitat Internacional de Catalunya, Barcelona · Universitat Politècnica de Catalunya (UPC), Barcelona · ICREA – Catalan Institution for Research and Advanced Studies, Barcelona · University of Alcalá, Madrid · Alfonso X el Sabio University, Madrid · Euneiz University, Vitoria-Gasteiz · Clínica Ortiz-Vigón PerioCentrum / ThinkingPerio Research, Bilbao · Clínica Guerrero, Marbella · Brånemark Clinic, Las Palmas · CICOM, Badajoz
ItalyUniversity of Padua · University of Trento · University of Turin · University of Ferrara · University of Modena and Reggio Emilia · Istituto Italiano di Tecnologia, Ferrara · University of Siena
SwedenUniversity of Gothenburg (Sahlgrenska Academy) · Public Dental Service, Region Västra Götaland · Uppsala University · Karolinska Institutet, Huddinge · Public Dental Health Services Stockholm · Kami Dental, Enköping
United StatesUniversity of Michigan · Harvard School of Dental Medicine · Rutgers School of Dental Medicine · New York University College of Dentistry · Sioux Falls Family and Implant Dentistry, South Dakota
ChinaShanghai Jiao Tong University (Ninth People’s Hospital) · Sun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
FranceAix-Marseille University · Assistance Publique – Hôpitaux de Marseille (AP-HM) · IHU Méditerranée Infection · Institut de Recherche pour le Développement (IRD)
GermanyGoethe University Frankfurt (Carolinum and University Hospital) · University Hospital Düsseldorf · Charité – Universitätsmedizin Berlin
JapanThe Nippon Dental University Niigata Hospital · Tokyo Medical and Dental University · Kanagawa Dental University
Saudi ArabiaUmm Al-Qura University, Makkah · Najran University · Dar Al Uloom University, Riyadh
ChileUniversidad de La Frontera, Temuco · Universidad de Antofagasta
United KingdomKing’s College London · University of Birmingham
BrazilFederal University of Santa Catarina, Florianópolis
Dominican RepublicUniversidad Federico Henríquez y Carvajal, Santo Domingo
EgyptQena University, Qena
JordanUniversity of Jordan, Amman
New ZealandUniversity of Otago (Sir John Walsh Research Institute), Dunedin
PeruUniversidad Científica del Sur, Lima
South KoreaGangneung-Wonju National University
SwitzerlandUniversity of Bern
United Arab EmiratesMohammed Bin Rashid University of Medicine and Health Sciences, Dubai

Investigators 141 named authors, each counted once

Alphabetical by family name. Listing an author here records only that they published a paper in which the NiTi Brush was used; it implies no relationship with, or endorsement of, HANS Korea.

  • Ingemar AbrahamssonUniversity of Gothenburg · Public Dental Service, Region Västra Götaland
  • Sultan AlanaziNajran University
  • Christine AlbrechtGoethe University Frankfurt
  • Lamija AlibegovicUniversity of Gothenburg
  • Ettore AmerioUniversitat Internacional de Catalunya, Barcelona
  • Angéline AntezackAix-Marseille University · AP-HM, Marseille · IHU Méditerranée Infection, Marseille · IRD, Marseille
  • Conrado AparicioUniversitat Politècnica de Catalunya, Barcelona · ICREA, Barcelona
  • Juan Manuel AragonesesUniversidad Federico Henríquez y Carvajal, Santo Domingo · Euneiz University, Vitoria-Gasteiz
  • Momen A. AtiehUniversity of Otago, Dunedin · Mohammed Bin Rashid University, Dubai · University of Jordan, Amman
  • Walaa BabgiUmm Al-Qura University, Makkah
  • Nicola BaldiniUniversity of Siena
  • Shayan BarootchiUniversity of Michigan · Harvard School of Dental Medicine
  • Jürgen BeckerUniversity Hospital Düsseldorf
  • Kathrin BeckerUniversity Hospital Düsseldorf · Charité – Universitätsmedizin Berlin
  • Amira BegicGoethe University Frankfurt
  • Georgios N. BelibasakisKarolinska Institutet, Huddinge
  • Pierantonio BelliniUniversity of Modena and Reggio Emilia
  • Víctor BeltránUniversidad de La Frontera, Temuco
  • Tord BerglundhUniversity of Gothenburg · Public Dental Service, Region Västra Götaland
  • Jessica Berglundh-GottliebUniversity of Gothenburg
  • Jessika BertacchiniUniversity of Modena and Reggio Emilia
  • Giulia BertaniUniversity of Modena and Reggio Emilia
  • Laura BertoniUniversity of Modena and Reggio Emilia
  • Michele BianchiUniversity of Modena and Reggio Emilia
  • Elisabeth A. BoströmKarolinska Institutet, Huddinge · Public Dental Health Services Stockholm
  • Kostas BougasUniversity of Gothenburg
  • Eriberto BressanUniversity of Padua
  • Arthur BrincatAix-Marseille University · AP-HM, Marseille
  • Giulia BrunelloUniversity Hospital Düsseldorf · University of Padua · Charité – Universitätsmedizin Berlin
  • Emilio A. CafferataGoethe University Frankfurt · Universidad Científica del Sur, Lima
  • Gianluca CarnevaleUniversity of Modena and Reggio Emilia
  • Beom-Seok ChangGangneung-Wonju National University
  • Shoucheng ChenSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Zhuofan ChenSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Enrico ConservaUniversity of Modena and Reggio Emilia
  • Ugo ConsoloUniversity of Modena and Reggio Emilia
  • Gunnar DahlénUniversity of Gothenburg
  • Shudan DengSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Jan DerksUniversity of Gothenburg · Public Dental Service, Region Västra Götaland
  • Carlotta DionigiUniversity of Gothenburg
  • Cristian Docampo-VázquezUniversidad Alfonso X El Sabio, Madrid
  • Mauro DonatiUniversity of Gothenburg
  • Warwick J. DuncanUniversity of Otago, Dunedin
  • Abdel Naser M. EmamNajran University
  • Mathias Faure-BracAix-Marseille University · AP-HM, Marseille
  • Baher FelembanUmm Al-Qura University, Makkah
  • Maria Elisa Galarraga-VinuezaGoethe University Frankfurt · Federal University of Santa Catarina, Florianópolis
  • Juan Daniel GamonalComplutense University of Madrid
  • Paolo GhensiUniversity of Trento
  • Adrián GuerreroClínica Guerrero, Marbella
  • Anders GustafssonKarolinska Institutet, Huddinge
  • Kazuhiko HiroyasuThe Nippon Dental University Niigata Hospital
  • Baoxin HuangSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Zhuwei HuangSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Yuki IchiokaUniversity of Gothenburg
  • Annsofi JohannsenKarolinska Institutet, Huddinge
  • Gunnar JohannsenKarolinska Institutet, Huddinge
  • Anthony KaoUniversity of Otago, Dunedin
  • Karolina KarlssonUniversity of Gothenburg · Public Dental Service, Region Västra Götaland
  • Shohei KasugaiTokyo Medical and Dental University
  • Seul-Kee KimGangneung-Wonju National University
  • Edward R. KusekSioux Falls Family and Implant Dentistry, Sioux Falls
  • Lena LarssonUniversity of Gothenburg
  • Jae-Kwan LeeGangneung-Wonju National University
  • Si Young LeeGangneung-Wonju National University
  • Neelam LingwalGoethe University Frankfurt
  • Ronaldo Lira-JuniorKarolinska Institutet, Huddinge
  • Xingchen LiuSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Alice LunghiIstituto Italiano di Tecnologia, Ferrara · University of Ferrara
  • Sunyoung MaUniversity of Otago, Dunedin
  • Ricardo MaginiFederal University of Santa Catarina, Florianópolis
  • Sebastian MalmqvistKarolinska Institutet, Huddinge
  • Chiara MalpassiUniversity of Siena
  • Andrea Martín-VacasUniversidad Alfonso X El Sabio, Madrid
  • Tsuyoshi MatsuuraTokyo Medical and Dental University
  • Alberto MonjeUniversity of Michigan · Universitat Internacional de Catalunya, Barcelona · University of Bern · CICOM, Badajoz
  • Virginie Monnet-CortiAix-Marseille University · AP-HM, Marseille · IHU Méditerranée Infection, Marseille · IRD, Marseille
  • Motohiro MunakataKanagawa Dental University
  • Gyula NagyUppsala University
  • Krunal NarendrakumarUniversity of Birmingham
  • José NartUniversitat Internacional de Catalunya, Barcelona
  • Paolo NavaUniversity of Michigan
  • José Manuel NavarroBrånemark Clinic, Las Palmas
  • Sofía Navarro-MesaBrånemark Clinic, Las Palmas
  • Paula NuevoComplutense University of Madrid
  • Karina ObrejaGoethe University Frankfurt
  • Romain OhanessianAix-Marseille University · AP-HM, Marseille
  • Giulia OrlandiUniversity of Modena and Reggio Emilia
  • Alberto Ortiz-VigónClínica Ortiz-Vigón PerioCentrum, Bilbao · Complutense University of Madrid
  • Camila PanesUniversidad de La Frontera, Temuco
  • Se Hwan ParkGangneung-Wonju National University
  • Lucrezia Parma-BenfenatiUniversity of Ferrara · University of Michigan
  • Stefano Parma-BenfenatiUniversity of Turin
  • Pedro Peñaprivate practice, Madrid
  • Alessandra PisciottaUniversity of Modena and Reggio Emilia
  • Ramón PonsUniversitat Internacional de Catalunya, Barcelona · Universitat Politècnica de Catalunya, Barcelona
  • Daniel PrimetzhoferUppsala University
  • Talat QadriKami Dental, Enköping
  • Clemens RaabeGoethe University Frankfurt · University of Bern
  • Ausra RamanauskaiteGoethe University Frankfurt
  • Nicole RauchUniversity Hospital Düsseldorf
  • Erik RegidorClínica Ortiz-Vigón PerioCentrum, Bilbao
  • Malcolm ReidUniversity of Otago, Dunedin
  • Mario RomandiniComplutense University of Madrid
  • Marisa RoncatiUniversity of Ferrara
  • Paul S. RosenNew York University College of Dentistry · Rutgers School of Dental Medicine
  • Robert SaderGoethe University Frankfurt
  • Camille SadowskiAix-Marseille University · AP-HM, Marseille
  • Muhammad H. A. SalehUniversity of Michigan
  • Mariano SanzComplutense University of Madrid
  • Dennis Schallerprivate practice, Planegg
  • Frank SchwarzGoethe University Frankfurt
  • Anton SculeanUniversity of Bern
  • Paola SenaUniversity of Modena and Reggio Emilia
  • Adrián Pappolla Sessaprivate practice, Toledo
  • Cristian Pappolla SessaUniversidad de Alcalá, Madrid · Universidad Alfonso X El Sabio, Madrid
  • Angelika SilbereisenKarolinska Institutet, Huddinge
  • Mariano del SolUniversidad de La Frontera, Temuco
  • Costanza SoldiniUniversitat Internacional de Catalunya, Barcelona
  • Omar Hassan SolimanQena University, Qena
  • Vanessa SousaKing's College London
  • Akihiro SuzukiTokyo Medical and Dental University
  • Noriko TachikawaTokyo Medical and Dental University
  • Nadia TagliaferriUniversity of Modena and Reggio Emilia
  • Dennis TarnowNew York University College of Dentistry
  • Andrew Tawse-SmithUniversity of Otago, Dunedin
  • Rosanna Di TincoUniversity of Modena and Reggio Emilia
  • Cristiano TomasiUniversity of Gothenburg
  • Anna Trullenque-ErikssonUniversity of Gothenburg
  • Heung-Sik UmGangneung-Wonju National University
  • Iván Valdivia-GandurUniversidad de Antofagasta
  • Federica VeneriUniversity of Modena and Reggio Emilia
  • Carlos VeutheyUniversidad de La Frontera, Temuco
  • Javi VilarrasaUniversitat Internacional de Catalunya, Barcelona
  • Leire VirtoComplutense University of Madrid
  • Hom-Lay WangUniversity of Michigan
  • Jiaxin XieSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Chunxin XuSun Yat-sen University, Guangzhou · Guangdong Provincial Key Laboratory of Stomatology · Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
  • Salah A. YousiefDar Al Uloom University, Riyadh
  • Giorgio ZappaláBrånemark Clinic, Las Palmas
  • Wenjie ZhouGoethe University Frankfurt · Shanghai Jiao Tong University

Patients and implants by study clinical studies only, cohorts counted once

StudyPatientsImplantsFollow-upCounted?
Derks et al. 2022 · multicentre RCT13814712 monthsYes
Alibegovic et al. 2025 · 3-year report of the same trial12012736 monthsSame cohort — not added
Monje et al. 2025 · multicentre RCT (surface decontamination)58≥ 5812 monthsYes
Monje, Pons, Peña 2024 · single-centre report of that trial192312 monthsSubset — not added
Regidor et al. 2023 · RCT (resorbable membrane)434312 monthsYes
Regidor et al. 2026 · RCT (adjunctive electrolytic cleaning)404412 monthsYes
Malmqvist et al. 2025 · RCT, flap-surgery arm (the arm in which the brush was used)12126 monthsYes
Monje et al. 2023 · RCT (barrier membrane)334812 monthsYes
Monje et al. 2023 · defect angle (secondary analysis)334812 monthsSame cohort — not added
Monje et al. 2026 · quasi-randomised trial (extent of implantoplasty)334012 monthsYes
Monje et al. 2025 · rhPDGF-BB case series101312 monthsYes
Zhou et al. 2026 · retrospective cohort, Frankfurt, 2018–2023223406mean 30.8 monthsYes
Schwarz et al. 2023 · retrospective, Frankfurt, 2018–2021364012 monthsSame centre and period as Zhou et al. 2026 — not added
Galarraga-Vinueza et al. 2020 · pilot20286 monthsYes
Monje et al. 2021 · retrospective (implantoplasty)43135about 24 monthsYes
Brincat et al. 2023 · case series579112–42 monthsYes
Babgi & Felemban 2024 · two cases22—Yes
Parma-Benfenati et al. 2026 · 10-year case report11120 monthsYes
Soliman et al. 2026 · split-mouth RCT (autogenous bone vs xenograft)102012 monthsYes
Total counted723≥ 1,0886~120 months

Translational and laboratory studies (Dionigi et al. 2025; Brunello et al. 2025; Kao et al. 2024; Ichioka et al. 2022 and 2023; Kim et al. 2016; Suzuki et al. 2014; Liu et al. 2023; Tagliaferri et al. 2024; Panes et al. 2024, an animal study; Narendrakumar 2015, a doctoral thesis) and reviews (Pappolla Sessa et al. 2025; Hiroyasu 2018; Kusek 2015; Regidor et al. 2023) contribute authors, institutions and countries but no patients. Revision 2 · 12 October 2026. This page is revised, with a new revision number, whenever a paper is added or removed.