Independently published, internationally
Since the NiTi Brush was launched in 2011, researchers and clinicians outside HANS Korea have used it as the mechanical decontamination step in published studies of peri-implantitis therapy — including multicentre randomised controlled trials.
Research groups in the United States, Germany, Japan, Switzerland, Sweden, Spain, Denmark, Italy, France, Brazil, Saudi Arabia, New Zealand, the United Arab Emirates and Jordan. Figures compiled by HANS Korea from the publications listed below (Literature Search Report HKLS-001).
Sixteen is a floor, not a census. A paper is listed here only when we have read it in full, verified it against the publisher's record, and the instrument in it is identifiable as the NiTi Brush from HANS Korea. Studies that report merely “a titanium brush” are left out, even where we have reason to believe the instrument was ours. The standard is strict on purpose: every entry below can be checked.
HANS Korea is not the publisher of any of these works, holds no copyright in them and has no commercial relationship with the journals. The summaries below are written by HANS Korea for orientation only — please read the original publication, linked with each entry, for the authors' own findings and conclusions.
All 16 references in one document — journal, DOI, authors, a short summary and a direct link to each original publication. The papers themselves are the copyright of their authors and publishers, so please obtain the full texts from the publishers using the links provided.
Randomised controlled trials
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Reconstructive surgical therapy of peri-implantitis: a multicentre randomised controlled clinical trial
DOI: 10.1111/clr.13972
A multicentre trial in 138 patients (147 implants) comparing access flap surgery alone against reconstructive surgery using a bone substitute material, with clinical and radiographic assessment to 12 months.
Outcome. At 12 months, 16.4% of reconstructed and 13.5% of access-flap implants met the composite success criteria; pocket-depth reduction (about 3.7 mm) and bone gain (about 1.0 mm) were similar in both arms.
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The adjunctive effect of a resorbable membrane to a xenogeneic bone replacement graft in the reconstructive surgical therapy of peri-implantitis: a randomised clinical trial
DOI: 10.1111/jcpe.13796
Forty-three patients treated with a xenogeneic bone substitute, randomised to receive a resorbable collagen membrane over the graft or not, assessed clinically and radiographically.
Outcome. At 12 months no implant was lost; treatment success was 36.8% with the membrane and 45.0% without (p = 0.61) — the membrane added nothing measurable to the graft.
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Significance of barrier membrane on the reconstructive therapy of peri-implantitis: a randomised controlled trial
DOI: 10.1002/JPER.22-0511
Thirty-three patients (48 implants) with contained defects, treated with a mineralised and demineralised allograft mixture with or without a cross-linked barrier membrane, and followed for 12 months. In this protocol the implant surface was decontaminated with a NiTi brush at 600 rpm before grafting.
Outcome. At 12 months mean disease resolution was 77.1%, and the barrier membrane did not improve it (OR 1.55, p = 0.737). Decontamination with the NiTi brush at 600 rpm was the step common to both arms.
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Electrolytic surface decontamination in the reconstructive therapy of peri-implantitis: single-centre outcomes of a randomised controlled trial
DOI: 10.11607/prd.7151
A single-centre analysis comparing an electrolytic method against hydrogen peroxide, each used as an adjunct to mechanical decontamination, at 12-month follow-up.
Outcome. At 12 months disease resolution reached about 91% with the electrolytic adjunct, roughly 16 points above hydrogen peroxide, but the difference was not statistically significant — both arms rested on the same mechanical debridement.
Clinical studies & retrospective analyses
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Effectiveness of modified and control protocols for the surgical therapy of combined peri-implantitis-related defects: a retrospective analysis
DOI: 10.1111/clr.14057
Thirty-six patients (40 implants) with combined supra- and intrabony defects, comparing a control protocol against two modified augmentation protocols at 6 and 12 months. All protocols included access flap surgery, granulation tissue removal and implant surface decontamination with a titanium brush.
Outcome. At 12 months median bleeding on probing fell by 58–67% and pocket depth by 0.8–2.0 mm across the three protocols; implant-surface decontamination with a titanium brush was the step shared by all three.
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Volumetric assessment of tissue changes following combined surgical therapy of peri-implantitis: a pilot study
DOI: 10.1111/jcpe.13335
Twenty patients (28 implants) followed for six months with intra-oral scanning, measuring the volumetric change of the peri-implant mucosa after combined surgical therapy. This is the paper that names Hans Korea Co., Ltd. as the source of the titanium brush used for decontamination.
Outcome. Peri-implant soft tissue thinned by 0.11 mm at 1 month and 0.28 mm at 6 months, and the contour area contracted 7.9% then 18.5% — a quantified picture of healing after therapy in which the exposed surface was decontaminated with a titanium brush (Hans Korea Co., Ltd.).
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Resolution of peri-implantitis by means of implantoplasty as adjunct to surgical therapy: a retrospective study
DOI: 10.1002/JPER.21-0103
Forty-three patients (135 implants) followed for a mean of about 24 months, evaluating implantoplasty as an adjunct to resective and reconstructive surgical therapy.
Outcome. Over a mean of about 24 months, therapeutic success was 66% or 79.5% depending on the case definition, and implant survival 97.8% across 135 implants.
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Defect angle as prognostic indicator in the reconstructive therapy of peri-implantitis
DOI: 10.1111/cid.13244
A secondary analysis of a randomised trial (33 patients, 48 implants) examining whether defect configuration, defect angle, defect width and baseline bone level predict the outcome of reconstructive surgery.
Outcome. Defect angle strongly predicted bone gain (p < 0.001): a 40° defect gained 1.85 mm, angles under 57° gained at least 1 mm and under 30° at least 2 mm.
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Absence of progressive bone loss following peri-implantitis surgical therapy with implantoplasty: a case series
DOI: 10.3390/app13127224
A case series assessing the absence of progressive marginal bone loss from one year to more than three years after reconstructive, apically repositioned flap, or combined surgical therapy with implantoplasty.
Outcome. Over 12–42 months (mean 24), 96.7% of 91 implants showed no progressive bone loss; three implants were removed.
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Management of early dental implant complication: a report of two cases
DOI: 10.54940/ms75920247
Two cases of early peri-implant complication managed by flap elevation, granulation tissue removal, mechanical cleaning of the implant surface with a titanium brush, and bone grafting.
Outcome. Both early complications resolved: radiographic bone fill around the implants at 4–5 months and healthy peri-implant tissue at the time of restoration. The implant surface was cleaned with the NiTi Brush Omega (HANS Korea) on a low-speed handpiece.
In vitro studies
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The effect of NiTi brush, polishing brush and chemical agent on the dental implant surface morphology and cytocompatibility
DOI: 10.1111/cid.13417
Titanium disks with a sand-blasted, acid-etched surface were treated with diamond polishing brushes, nickel-titanium brushes, or a phenol and sulphuric acid gel, then examined by scanning electron microscopy, surface roughness measurement and cell viability assay. The authors report that none of the protocols compromised cytocompatibility, that operative time was shorter for the NiTi group than for the polishing brush group, and that the best cell-viability results were recorded in the NiTi group when samples were stored in saline.
Outcome. The NiTi Brush (NANO, HANS KOREA) left surface roughness close to the original, gave the highest cell viability of the protocols tested when discs were stored in saline (p ≤ 0.001), and was faster than the diamond polishing brush — 48.2 versus 54.9 seconds (p = 0.017).
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Quantity and size of titanium particles released from different mechanical decontamination procedures on titanium discs: an in vitro study
DOI: 10.3390/dj12050123
One hundred and forty moderately roughened titanium discs in seven groups — metal-tip and PEEK-tip ultrasonic scaling at two power settings, erythritol air-polishing, and a rotary brush — with the rinsing solution analysed by ICP-MS for titanium mass and by SEM for particle size. The rotary brush was the NiTi Brush Omega (Hans Korea), named in the methods.
Outcome. The NiTi Brush released 6.45 ± 2.03 µg of titanium per disc — about one-fifth of metal-tip ultrasonic scaling (34.0–34.4 µg), a statistically significant difference — with particles of comparable size (1.05 µm). Air-polishing and the PEEK tip released less.
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Evaluation of biological response of STRO-1/c-Kit enriched human dental pulp stem cells to titanium surfaces treated with two different cleaning systems
DOI: 10.3390/ijms20081868
A comparison of Ni-Ti brushes against air polishing with bicarbonate powder on machined and Ca²⁺-nanostructured titanium surfaces, examining the effect on surface properties, on human dental pulp stem cell behaviour and on bacterial biofilm formation.
Outcome. Air-polishing with bicarbonate removed about 99% of biofilm without altering the surface, whereas the Ni-Ti brush (I.C.T. Brush micro, Hans Korea) modified the surface and, on nanostructured discs, reduced stem-cell marker expression. A study that favoured the gentler method on that specific surface — reported here as published.
Reviews
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Mucositis and peri-implant disease treatment with chitosan and titanium brushes: a systematic review
DOI: 10.3390/jcm14238306
A systematic review of nine studies — seven randomised controlled trials and two prospective case series — on chitosan and titanium brushes in the treatment of peri-implant disease. The titanium brush illustrated in the paper is the POCKET® model (Hans Korea).
Outcome. The review concludes that titanium brushes effectively reduce probing depth and bleeding, are safe, and perform best within surgical protocols combined with regenerative materials — while showing no clear superiority over other techniques in between-group comparisons.
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Minimal invasiveness in the reconstructive treatment of peri-implantitis defects
DOI: 10.1111/prd.12460
A review of minimally invasive approaches to reconstructive peri-implantitis treatment, covering flap design, barrier membranes, bioactive molecules and antimicrobial adjuncts, and the balance between minimising surgical trauma and retaining adequate access for implant surface decontamination.
Outcome. A narrative review. It concludes that a minimally invasive approach optimises the outcome of reconstructive therapy while limiting post-operative complications; no quantitative result.
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安心・安全なインプラント治療を行うために — Toward safe and secure implant treatment
A review of the current workflow of implant therapy in Japan, the evolution of the field, and the management of peri-implant complications. In the section on peri-implantitis the author describes polishing the exposed rough implant surface with a titanium brush to convert it to a smooth surface, limiting further deposit adhesion and bone resorption. Figure 8 of the paper illustrates this step and identifies the instrument as the NiTi Brush (HANS Korea).
Outcome. A review of implant therapy in Japan. For peri-implantitis the author polishes the exposed rough surface to a smooth one with a titanium brush to prevent further deposits; Figure 8 identifies the instrument as the NiTi Brush (HANS Korea).
Bibliographic details are reproduced for identification and citation. Copyright in each publication remains with its authors and publisher. See the legal notice for details.