Monje A, Navarro-Mesa S, Soldini C, Zappalà G, Peña P, Navarro JM Sr, Pons R. Clinical Implant Dentistry and Related Research 2025;27(4):e70075. doi:10.1111/cid.70075
Summary prepared by 
— not the original paper
Why we present this paper
This page is published by HANS KOREA CO.,Ltd., the manufacturer of the NiTi Brush1. We share selected peer-reviewed studies so that clinicians who use the NiTi Brush can see how it was used in published clinical protocols, with the ultimate aim of better outcomes for patients.
Independence
The study was designed, conducted and published independently by its authors. The authors and the publisher are not associated with this page and do not endorse HANS Korea or its products. According to the paper, the study was supported by a research grant from Nobel Biocare (2021-1716), and the titanium brushes were provided by Sanhigia (Zaragoza, Spain). Sanhigia is HANS Korea’s distributor in Spain. According to the paper’s conflict-of-interest statement, two of the authors received fees for lecturing and other education-related events from Nobel Biocare and Straumann, and none of the authors have any direct conflicts of interest with any of the instruments or materials listed in the paper.
About this study
This paper compares two adjunctive surface decontamination methods — an electrolytic method and hydrogen peroxide — in the reconstructive surgical therapy of peri-implantitis with crater-like and circumferential intrabony defects. As part of the surgical protocol described by the authors, NiTi brushes were used for surface decontamination in both groups, before the adjunctive method was applied.
How the NiTi Brush was used in this study
As reported by the authors.
| Item | As reported in the paper |
|---|---|
| Instrument | NiTi Brush (HANS Korea), named in the paper as “NiTi brushes” with the manufacturer given as Hans Korea Co., Gyeonggi-do, Korea |
| Step in the protocol | Surface decontamination (the authors’ term), after debridement of granulation tissue with curettes and before the adjunctive decontamination step, in both groups |
| Speed | 600 rpm |
| Brushing time | Approximately 2–3 minutes |
| Irrigation | The paper does not state whether irrigation was used while brushing; brushing was followed by the adjunctive method (electrolytic method or hydrogen peroxide 3%, 2 minutes each) and irrigation with saline |
The study at a glance
Multicenter randomized clinical trial at three centers in Spain (NCT05615051): 58 patients completed the study, with clinical evaluation at baseline, 6 and 12 months and radiographic assessment at baseline and 12 months; the defects were reconstructed with autogenous bone mixed with a bovine bone substitute and covered with a collagen membrane. The authors conclude that both tested surface decontamination methods are effective in resolving peri-implantitis, in gaining radiographic marginal bone levels and in enhancing clinical peri-implant conditions in surgical reconstructive therapy.
Please read the original paper
For the methods, results and limitations, see the original article (open access): https://doi.org/10.1111/cid.70075
Reported study conditions are the authors’ and may differ from the Instructions for Use. Use the NiTi Brush only as described in the IFU (implant motor, 600–1,200 rpm, external saline irrigation, single use).
Source: Monje A, Navarro-Mesa S, Soldini C, Zappalà G, Peña P, Navarro JM Sr, Pons R. Clin Implant Dent Relat Res 2025;27(4):e70075, © 2025 The Author(s), published by Wiley Periodicals LLC, open access under the Creative Commons Attribution License (CC BY). Summary and table by HANS Korea; wording adapted.
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1 The NiTi Brush is a rotary brush with nickel-titanium alloy bristles, developed by HANS Korea since 2010. Rotary brushes of this kind are generically called “titanium brushes” (see What is a titanium brush); the official product name is NiTi Brush for Peri-implantitis. ↩